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Symptoms of vitamin B12 deficiency include: a pale-yellow tinge to the skin a sore and red tongue (glossitis) mouth ulcers pins and needles (paraesthesia) changes in the way a person walks and move around disturbed vision irritability depression The chance of developing vitamin B12 deficiency can increase due to the following risk factors: older age high alcohol consumption pernicious anemia atrophic gastritis (inflammation in the stomach) Helicobacter pylori infection celiac disease Crohns disease gastrointestinal surgery history following a plant-based diet pancreatic insufficiency AIDS some hereditary conditions that affect the vitamin B12 absorption It is crucial to note that Vitamin B12 injections are available by prescription only following a clinical diagnosis of low B12 levels
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Although currently mostly in preclinical studies, this co-delivery strategy is expected to gradually move toward clinical application as delivery systems improve and more pharmacokinetic/toxicological data accumulate (Table 4)
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