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These recommendations are based on results that showed that GLP-1RA compared with insulin therapy (basal, premixed, or intensified basal-bolus regimens) have similar or even better efficacy in HbA1c reduction and a lower hypoglycemia risk, promotes weight loss instead of weight gain, and reduces the burden of drug administration frequency and self-monitoring of blood glucose [1, 2]
We targeted a GLP-1-RA concentration and dosage relevant to human equivalent dosing of semaglutide (clinical dosing of semaglutide is 1 mg weekly) ( 49, 50 ), for evaluation in a rat model of insulin-impaired diabetes
All authors participated in critical review of the manuscript
This helps stabilize hydration and energy needs
