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Medications that can enhance the activity of insulin (so-called incretin mimetics) can help to overcome insulin resistance caused by SGAs (and potentially by other psychotropic medications) and essentially lead to weight loss through enhanced fuel efficiency. Metformin, typically dosed up to 1,000 mg twice daily with meals, has increasingly become recognized as a first-line strategy to attenuate weight gain and glycemic dysregulation from SGAs via its ability to reduce insulin resistance

Kinugasa Y, Sota T, Nakamura K, Hirai M, Kato M, Yamamoto K

As usual, the story is incomplete

For example, a manual FDS injection device could be used in clinical trials, but an FDS autoinjector could be the commercial embodiment, he says