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The myocardium of HFpEF patients abnormally retains cellular calcium, which adversely affects SR function, leading to prolonged relaxation and a build-up of diastolic tone [22,23]
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Eligible participants had a body mass index (BMI) 30 kg/m (obesity) or a BMI 27 kg/m with obesity-related comorbidities, such as hypertension or hyperlipidemia (overweight with comorbidities)
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