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For instance, MC4R intracerebroventricular administration has been shown to induce the gene transcription of cortisol releasing hormone with effects blocked by administration of an MC4R antagonist [42]
GSTs are also involved in the phase I detoxification process such as dehydrochlorination of 1,1,1-Trichloro-2,2-bis( p -chlorophenyl) ethane (DDT) to less toxic 1,l-Dichloro-2,2-bis( p -chlorophenyl) ethylene (DDE) [22, 43, 44]
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