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To offset these pressures, Ipsen has successfully launched Iqirvo (elafibranor) for primary biliary cholangitis and Bylvay (odevixibat) for rare liver diseases, and acquired multiple innovative pipeline assets in 2024

Reductions in liver enzymes (ALT, AST) and improvements in non-invasive fibrosis markers were also observed

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Also, OGC and DIC together accounted for only an apparent 4550% of the total GSH uptake in liver mitochondria, in contrast to 7080% described in kidney mitochondria (Zhong et al., 2008)