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However, they may be particularly beneficial for those who are over the age of 30 or who have a deficiency in GH

In terms of weight reduction outcomes, tirzepatide (22.5% at 72 weeks) sits between semaglutide (16% at 68 weeks) and retatrutide (24.2% at 48 weeks)

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In these populations, GLP-1 medications may: Suppress appetite in ways that destabilize recovery Mask symptoms without addressing underlying drivers Increase psychological distress related to food, weight, or control Any consideration of GLP-1 use should involve careful medical oversight, psychological evaluation, and ongoing monitoring