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In terms of functional characterization, human CT2 can transport L-carnitine with a Km of 20.3 M
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Currently, there is a lack of any systematic animal and clinical studies with COPD as an indication, so regulating copper homeostasis should be viewed as a highly experimental direction primarily focused on mechanism validation, with a long way to go before it can be considered for clinical strategies in COPD patients (273)
Differential effects between marimastat, a TNF- converting enzyme inhibitor, and anti-TNF- antibody on murine models for sepsis and arthritis
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