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To minimize these events, Sean Wharton, MD, director of the Wharton Medical Clinic in Toronto, and colleagues suggest the three Es: E ducation and explanation E scalation to an appropriate dose E ffective management of GI side effects. Patients should be counseled on means to decrease adverse event risk such as reducing meal size
New England Journal of Medicine ): STEP UP Clinical Trial / FDA Approval (March 2026): Evaluated the safety and efficacy of the newly approved once-weekly semaglutide 7.2 mg (Wegovy HD) for chronic weight management
At this time, its unclear about the long-term ramifications of this decision
Other investigators have suggested that a NOS-related pathway may also contribute to improve insulin release
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