TMAO: how gut microbiota contributes to heart failure
While anecdotal reports and some preliminary research suggest that it may aid in weight reduction by promoting gut health and improving metabolic function, there is currently insufficient scientific evidence to validate these claims fully
Back Hendershot, CS, Bremmer, MP, Paladino, B, et al (12 Feb 2025) 'Once-weekly semaglutide in adults with alcohol use disorder: A randomized clinical trial', JAMA Network, 82/4, 395-405.Back 'Scientists pioneer two techniques to combat obesity', The Guardian
The objective of this study was to compare the efficacy and safety of tirzepatide with titrated insulin degludec in individuals with type 2 diabetes who had inadequate glycemic control despite treatment with metformin alone or in combination with SGLT2 inhibitors.In this phase 3 study, participants aged 18 years or older, with a baseline glycated hemoglobin (HbA1c) of 7.0-10.5%, body mass index of at least 25 kg/m2, stable weight, and no prior insulin treatment, were enrolled across multiple centers in 13 countries