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The peptide works by triggering sustained gene expression changes that require consistent signaling

Estrogen decline, insulin resistance, and midlife weight gain in menopause The transition to menopause is associated with a decline in estrogen, demonstrating an important link between hormonal changes, insulin resistance, and the common experience of midlife weight gain, particularly around the abdomen

Changes in proline and glutamate metabolism were associated with increased glutathione, while the gut microbiota shifted towards the composition of healthy controls