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IGF-1 exerts unique and stimulatory influences on the granulosa cells and according to reports increases the production of steroidogenic CYP19A1, 3-beta-hydroxysteroid dehydrogenase, CYP11A1, and the expression of IGF-1R and FSHR
One of the key members of the laboratory was Jens Rehfeld, a young Danish gastrointestinal researcher who gathered around him a dynamic circle of enthusiastic young doctors and doctoral students (figure 28) keen to research newly discovered gut peptides
The agent selection should be driven by dominant comorbidity: semaglutide for CVD/CKD, tirzepatide for maximum weight loss or MASH, liraglutide if weekly agents are unavailable
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