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Because the pigment sits deeper in the skin than some other types of discoloration, it can be more stubborn and more likely to come back
However, despite robust effects 35,36 , a large proportion, ~4050% of patients with SAD, has been reported to be either treatment resistant or not responding sufficiently to current treatments 37
Potential endpoints include: Dermal papilla cell viability Cell proliferation Growth-factor-associated measurements Extracellular-matrix markers Hair-cycle gene expression Organoid morphology Follicular structural measurements Time-dependent cellular responses Changes in follicular-cell markers do not establish hair growth, reduced hair loss, or a successful hair-regrowth application
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