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Microdosing involves the off-label use of GLP-1 medications (semaglutide and tirzepatide) at much smaller doses than the standard recommended dose, such as: Consuming a fraction of a starter dose, such as 0.05 mg of Ozempic instead of 0.25 mg
Frequent review (every 24 weeks) until target or tolerance is reached makes all the difference
In the next sections, we will detail these potential risks
In vascular macrophages, exendin-4 suppresses lipopolysaccharide-induced pro-inflammatory gene expression by activating the cAMP/PKA pathway and inhibiting NF-B nuclear translocation, further supporting a systemic immunomodulatory role (57)
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