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Its precisely why this class of medications cant be looked at as a shortcut to weight lossthey need to coexist with a high protein diet and strength training
This is covered in detail in the maintenance section, but briefly: people who have established ketogenic metabolic adaptation while on semaglutide appear better positioned to maintain their weight loss after discontinuation than people who relied purely on drug-mediated appetite suppression
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Other oral medications with narrow therapeutic windows medications such as certain thyroid medications and oral antibiotics that depend on consistent gastric absorption timing may be affected
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