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The evidence summary below is compound-level only
Typically, the E3 ubiquitin ligase complex comprised of Kelch-like ECH-associated protein 1-Cullin 3-Ring box 1 (KEAP1-CUL3-RBX1), S-phase kinase associated protein 1-Cullin 1-Rbx1/-transducin repeat-containing protein (SCF/-TrCP), and synonymin/Hrd1, continuously degrades Nrf2 proteasomes, maintaining Nrf2 at a low expression level [64]
Consequently, it is not for human use, and only trained professionals should handle it in controlled environments
Intravenous: Used in one pilot study but not recommended for mental health applications and requires medical supervision
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