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Reduced endothelial activation and leukocyte adhesion are particularly relevant to early vascular dysfunction

In the NY Times article, Richard DiMarchi, one of the early pioneers in GLP-1 research, states that many diseases may share the same root causes, even though we label them and treat them as distinct. I contend that virtually all chronic diseases are caused by constant metabolic disruption

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[24] [25] For some patients, returning to or optimising traditional oral agents such as metformin (if not already at maximum tolerated dose), sulphonylureas, or pioglitazone may be appropriate