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doi: 10.1097/01.mco.0000134362.76653.b2 139 BodenGRezvaniIOwenOE
They need sustained energy, sharp cognitive function, and emotional balance
This design is important because it tries to answer a more nuanced question than a simple exposed-versus-unexposed comparison
Phase 2 showed that participants who started at 4mg had nearly double the rate of gastrointestinal side effects compared to those who started at 2mg
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