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GLP-1 is broken down within 1 to 2 minutes of release in the body by the bodys enzymatic system, because it breaks down so quickly, native GLP-1 is not therapeutically useful as a drug
This narrative review synthesizes current preclinical and human evidence on the bidirectional interactions between GLP-1 RAs and the intestinal microbial ecosystem, with particular attention to microbial composition, metabolite production (including short-chain fatty acids and bile acids), intestinal barrier integrity, and inflammatory signaling
Most side effects are mild and go away over time
Patients should never self-combine prescription medications without clinician oversight
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