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Uterine immune dysregulation, including altered uNK abundance and functional imbalance, impaired macrophage-associated remodeling at the decidualtrophoblast boundary, and insufficient expansion of regulatory T cells, has been repeatedly implicated in early pregnancy loss [375,376,377]
While topical formulations have long been a staple, injection-based use introduces a fundamentally different approach that penetrates deeper and potentially produces more pronounced results
The net effect is the activation of cGMP-dependent protein kinase (PKG
However, in a study by Bezin and colleagues (2023), the use of GLP-1 RA for 1-3 years was associated with an increased risk of thyroid cancer and medullary thyroid cancer
