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This means that impatience during the escalation phase leads to premature dose increases that drive more side effects without proportional benefit

As an investigational medicine, its full safety profile will only become clearer through larger Phase 3 trials and, if approved, post-marketing surveillance

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Results of cellular thermal shift assay and molecular docking indicate that GPX4 is a potential direct target of carnosine, and carnosine shows promise as a potential inhibitor of ferroptosis for the treatment of renal I/R injury and other conditions associated with ferroptosis