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3 GLP-1R localization and mechanistic pathways in metabolic and behavioral regulation GLP-1 Rs exhibit high expression in pancreatic -cells in both rodents and humans, where they play a pivotal role in mediating glucose-dependent insulin secretion (Nauck et al., 1993

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The study suggests that strategies targeting the opioid system, both behaviorally and pharmacologically, could be important in addressing the obesity epidemic