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Abrupt discontinuation without appropriate alternative management may lead to deterioration in glycaemic control, which can increase the risk of diabetes-related complications

Activation of this pathway destroyed the expression of tight junction proteins such as zonula occludens-2 (ZO-2), occludin, and vascular endothelial cadherin (VE-cadherin) in endothelial cells, which increased endothelial cell permeability

The remaining 10% originates from the bulbourethral glands, the lumen of the seminiferous tubules, the epididymis, and the vas deferens (28)

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