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Acknowledgements We would like to thank Professor Hua Ge for her precious suggestion on dermatology, clinical data analyses and comments on the work

In particular, Phe286 6.58 and Phe290 6.62 , located at the entrance of the ligand-binding pocket, are thought to contribute to the accessibility of the acyl-modified peptide through their hydrophobic properties (You et al., 2023)

Some grains, like breakfast cereals and nutritional yeast, are also fortified with the nutrient ( On the contrary, liquid vitamin B12 supplements are made synthetically in laboratories using microbes and other chemical processes