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2.6 Probiotics and gut microbiota modulation The human gut microbiome has rapidly emerged as a critical and modifiable cancer susceptibility, treatment-response, and survivorship determinant, including in breast cancer where the paradigm has attracted attention to probiotics and gut-microbiota targeting as promising adjunctive strategies (174)

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Cardiovascular and Metabolic Benefits Identified Searches identified 3145 records, and after screening, 17 meta-analyses of 432 RCTs were included, covering 65 outcomes across cardiovascular, metabolic, oncologic, renal, GI, and other clinical domains

If appropriate, a treatment plan may include GLP-1 medication, along with nutritional and lifestyle guidance