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The transport of macromolecules can also occur via adsorptive-mediated transcytosis (AMT) [ Figure 3 (E) ] which is based on the electrostatic interactions resulting from the interaction between negatively-charged domains on the cellular membrane and positively-charged transporters

All these observations were confirmed and supported by in vitro experimental data, including evaluation of cytotoxic effects on healthy RBCs [269,270,271]

In a small study of 10 children aged 3 to 16, DSIP treatment improved abnormal brain electrical activity patterns in 9 out of 10 patients, demonstrating potential neuroprotective properties beyond sleep regulation