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Engages calcitonin receptorRAMP complexes for receptor specificity: Amylin receptors are heterodimeric complexes composed of calcitonin receptors coupled with receptor activity-modifying proteins (RAMPs)

They are thus suggested to have an open active site cleft to accommodate hydrolysis of large polymeric substrates like PGA (Wada et al., 2010

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Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved