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Intestinal proliferation and delayed intestinal transit in a patient with a GLP-1-, GLP-2- and PYY-producing neuroendocrine carcinoma

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Among them, only the GLP-1R x GCGR dual agonist, Mazdutide, developed by Innovent Biologics/Eli Lilly, has completed clinical trials and is seeking market approval

Subsequent studies demonstrated that apelin signaling is highly context dependent, with differential coupling to G_i, G_q, and -arrestin pathways depending on ligand structure, receptor density, and tissue environment ( Translationally, the apelinAPJ system illustrates a broader challenge for metabolic peptides with cardiovascular overlap: indication-specific development is likely required