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A-431 cells were cultured in RPMI-1640 supplemented with 10% FBS, for 2 days at 37 C and 5% CO 2

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Acknowledgements We would like to thank the families of individuals with autism for the thoughtful donation of post-mortem tissues to the Autism Tissue Program at the Harvard Brain Tissue Resource Center, Belmont, MA,USA, and the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland, Baltimore, MD, USA