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this list is not exhaustive Antacids Colchicine (treatment of gout) H2 Blockers (Zantac, Tagamet, Pepcid) Metformin Diabetes drug (Glucophage) PPIs Proton pump inhibitors (Omeprazole, Nexium, Prevacid, Protonix) Nitrous oxide anaesthesia Nitrous oxide recreational abuse (Laughing gas / Whippets / Hippy crack) Mycifradin sulphate (Neomycin) antibiotic Para aminosalicylates antibiotic Phenytoin (Dilantin) anti-epileptic Potassium chloride (K-Dur) Cholestyramine (Questran) Chemotherapy and radiation treatment Increased demands Chronic Hemoltic anaemia Hyperthroidism Multiple myeloma Myelopproliferative disorders Neoplasms Pregnancy Some patients may never find out the cause of their condition, this does not mean that they should be denied B12 injections which are, safe, inexpensive and the most efficient treatment for their deficiency

References Cell Metabolism (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee C, Zeng J, Drew BG, et al.) Journal of Translational Medicine (2023) Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging (Wan W, Zhang L, Lin Y, et al.) Journal of Molecular Medicine (2019) MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction (Lu H, Wei M, Zhai Y, et al.) Nature Communications (2021) MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis (Reynolds JC, Lai RW, Woodhead JST, et al.) Frontiers in Physiology (2023) Role of MOTS-c in the regulation of bone metabolism (Yi X, Hu G, Yang Y, et al.) Cognitive Vitality Reports (2021) MOTS-c (Cognitive Vitality Profile) Alzheimers Drug Discovery Foundation (ADDF) USADA Spirit of Sport (2023) What is the MOTS-c peptide

As scientists continue to unlock the molecular mysteries of aging, 5-Amino-1MQ stands out as a research target that requires more human safety and efficacy data in the quest for a healthier, longer life