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A Complete Insurance Guide At a glance Drug / apixaban (Eliquis), a Factor Xa inhibitor approved by the FDA in 2012 Typical formulary tier / Tier 3 or Tier 4 on most Anthem commercial plans Prior authorization required / Yes, on nearly all Anthem plan types Step therapy / Some Anthem plans require a trial of warfarin or rivaroxaban first Average retail price without insurance / $600, $650 per 30-day supply (5 mg twice daily) BMS/Pfizer copay card savings / Eligible commercially insured patients may pay as little as $10/month Medicare Part D coverage / Covered on most Anthem MediBlue plans, usually Tier 3 to 5 Key approved indications / Nonvalvular atrial fibrillation, DVT/PE treatment, DVT/PE prevention post-surgery Appeals success rate / Roughly 40 to 60% of prior-authorization denials are overturned on first appeal Generic availability / No FDA-approved generic apixaban as of early 2025 What Is Eliquis and Why Does Coverage Matter

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