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Cagrilintide is not a controlled drug under the Misuse of Drugs Act 1971, and it can be supplied lawfully in the UK as a research chemical

While some workaday compounding pharmacies have strong track records, research suggests that errors remain more common at compounding pharmacies than at large drug manufacturers

Animal research suggests oral BPC-157 can produce gut effects, but bioavailability data in humans is absent

What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation