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Indeed, recent studies using magnetic resonance imaging (MRI) to measure myelin water fraction suggest that obesity, along with conditions like hypertension and metabolic syndrome, is linked to reduced myelin content in the brain ( 2.7 Endoplasmic reticulum stress Endoplasmic Reticulum (ER) stress is a condition that arises from the abnormal buildup of misfolded and unfolded proteins within the ER lumen
Graphical abstract Similar content being viewed by others Introduction Sodiumglucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to reduce the incidence of cardiovascular and kidney disease in people with type 2 diabetes, ostensibly independent of their effects on blood glucose [1, 2]
This situation became further unclear in 1948 when Earl Sutherland and Christan De Duve, two biochemists at Washington University School of Medicine in St Louis, detected glucagon in gastric extracts (Holst 1983
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