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doi: 10.2337/dc18-2648 173 MirabelliMChiefariETocciVCaroleoPGiulianoSGrecoEet al
Learn more on ClinicalTrials.gov: CT-996 is a once daily oral small molecule agonist of the GLP-1 receptor being developed for the treatment of obesity and type 2 diabetes
For example, the p53 mutants p53 R 237 H and p53 R 175 H promote sensitivity to ferroptosis-like cell death, most likely through the combination of p53 mutants with NRF2 and through the suppression of the NRF2-dependent transactivation of SLC7A11 together with other antioxidant genes that oppose ferroptosis (Sasaki et al., 2002
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