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10.1016/j.phytol.2023.04.001 114 LuY.LiuR.BerthodA.PanY
The body needs both coenzyme forms because they are required for different reactions
For instance, tumor-associated macrophage (TAM)-derived CCL2 activates PI3K-AKT-mTOR signaling, promoting tamoxifen resistance in breast cancer via a prosurvival feedback loop
This phase includes sulfation (adding a sulfo group), glucuronidation (adding glucuronide), glutathione conjugation (pairing), acetylation (adding an acetyl group), amino acid conjugation, and methylation
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