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cGAS uniquely binds to DNA and catalyzes the synthesis of cyclic GMPAMP (cGAMP), a second messenger that activates STING, leading to the induction of interferon (IFN) responses via the transcription factor IRF3

doi: 10.1056/NEJMoa1212914 242 PownallHJSchwartzAVBrayGABerkowitzRILewisCEBoykoEJet al

Antibody-drug conjugates: recent advances in conjugation and linker chemistries