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These may signal that the medication is affecting the gastrointestinal system more than expected
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For this reason, the current approach is to reduce the dose by modifying the radiation field composition via nuclear fragmentation, namely by breaking ions into particles with lower charges and similar velocities, while avoiding the dose increase of the mixed field induced by the secondary particles (158)
GLP-1 receptor agonists such as semaglutide and the dual GIP/GLP-1 agonist tirzepatide act on appetite, satiety, and gastric emptying, with evidence from programs like STEP (NEJM, 2021), SURMOUNT (NEJM, 2022), and SURMOUNT-OSA (NEJM, 2024)
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