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In addition to experimental methods, theoretical methods [49,50,51,52,53] have been used to elucidate the properties and mechanisms of vitamin B12 cofactor catalysis in enzymatic processes [54,55,56,57,58,59]

These inadequacies emphasize the need for a more comprehensive, unifying mechanism to elucidate the complex relationship between CVDs and cognitive impairment at cellular and molecular levels, and underscore the urgency of further research into mitochondrias role in this comorbidity

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Thus, for wild-type glutaredoxins, formation of the transition state between the reduced enzyme and GSSCys (Fig