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They show some positive effects on sleep quality, such as restful sleep, but they dont show that melatonin supplements reverse the cognitive deficits of AD.[ref] One placebo-controlled trial of six months of 2mg time-release melatonin in people with mild to moderate AD did show positive results on cognitive performance compared to placebo
One tablet daily in 500ml water
PMC 3617579
3.2 Bipolar disorder (BD) Research has shown that people suffering from BD have an altered gut microbiome with much reduced amounts of useful organisms, such as Faecalibacterium , and increased amounts of potentially harmful taxa, such as Actinobacteria, which is featured as one of the alterations (Painold et al., 2019)
