They explain in an editorial for the South African Medical Journal that evidence shows, that on their own, recommendations for diet and exercise are unable to combat obesity and contribute to societal stigma and individual shame
Various studies have shown that 5-HT plays a vital role in regulating energy metabolism and suppressing appetite through various mechanisms, including improving insulin sensitivity and mediating intestinal functions (i.e., motility, secretion, absorption, and sensory) by directly acting on the enteric nervous system and hypothalamic AgRP and POMC neurons [132,133,134,135,136,137,138,139]
Expert Rev Pharmacoecon Outcomes Res
Statistics Quantitative data are expressed as mean SEM and qualitative data as a ratio