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High-dose oral therapy (10002000 micrograms daily) can effectively treat deficiency even in those with impaired intrinsic factor-mediated absorption, relying on passive diffusion

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NAD + -consuming enzymes include NAD + glycohydrolases (NADases) such as CD38 and sterile alpha and TIR motif containing 1 (SARM1), deacylases (sirtuins), and ADP-ribosyl transferases (PARPs)

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