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Patients should contact their GP or healthcare provider urgently if they experience: Severe, persistent abdominal pain, especially if radiating to the back (possible pancreatitis) Persistent vomiting or inability to keep fluids down (risk of dehydration) Difficulty swallowing or painful swallowing Unexplained weight loss Vomiting blood or passing black stools (seek immediate emergency care) Note that the 3 mg dose of Rybelsus is only for treatment initiation (30 days), and dose escalation to 7 mg (and later 14 mg if needed) can be delayed if gastrointestinal side effects persist

If you experience any of these symptoms, do not hesitate to contact your GP or NHS 111 for guidance

The rationale is that men typically carry more lean mass and have higher basal metabolic rates, potentially requiring slightly higher doses to achieve equivalent receptor activation per kilogram of body weight

25-39% The estimated proportion of weight lost on GLP-1 therapy that may come from lean mass rather than fat, based on body composition analyses from clinical trial data. The precise figure varies by patient, dose, and whether resistance exercise is incorporated