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Researchers became interested in this combination because early studies suggested that adding amylin pathway modulation to triple incretin agonism could produce synergistic effects beyond either component alone similar to how the CagriSema (cagrilintide + GLP1) combination outperformed individual components in clinical trials
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The body has a finite number of receptor sites
As adjuvant methods to boost coverage alongside the primary therapy, new probiotics (psychobiotics) or pharmabiotics containing bacteria that produce SCFAs and neuroactive metabolites are being researched
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