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Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer
Biological systems tend toward homeostasis, and prolonged interference with any single pathway component may trigger adaptive responses
107(6):771781 Endocrine and metabolic roles of insulin-like growth factor signaling in experimental models Sjgren K, Jansson JO, Isaksson OG, Ohlsson C., Minerva Endocrinologica , 2002
Use raw heart-rate change rather than placebo-subtracted when assessing drug-attributable load: the placebo arm shows real cardiovascular adaptation from weight loss and lifestyle counseling, so subtraction over-corrects
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