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When stored within cells, iron is complexed with a heteromeric protein called ferritin
308 Rather than harboring stable resistance mutations, DTP cells adopt a slow-cycling or quasiquiescent phenotype driven by extensive epigenetic remodeling, transcriptional plasticity and metabolic reprogramming, which collectively constitute core maintenance programs that stabilize the DTP state under therapeutic pressure
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In a study of mice by Everard A., et al
Amini, M
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