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These antibiotics accumulate within the endolymph, preferentially damaging outer hair cells in the basal cochlea, which results in high-frequency hearing loss, often the first detectable sign of aminoglycoside-induced ototoxicity (OSullivan et al
Furthermore, evidence indicates that NRF2 can transcriptionally upregulate CHAC1, as observed in ferroptosis-resistant melanoma cells where CHAC1 induction occurs independently of ER stress (Gagliardi et al., 2019) and modestly at the promoter level ( de novo GSH synthesis (Kre et al., 2023)
Are there any side effects of this combination Side effects are rare but may include mild stomach upset or headache
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