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These possible complications include the following: Birth defects, miscarriage, or premature birth if taken during pregnancy Joint or bone pain, abnormal bone growth, and osteoporosis (bone thinning or weakening) Visual issues, including reduced night vision Hearing impairment Rare buildup of pressure inside the head (pseudotumor cerebri), with symptoms like blurred vision and nausea Mental health challenges like mood swings, depression, anxiety, or suicidal thoughts

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The inhibition of interferon production and the delayed host response to the presence of the virus in cells leads to significant molecular perturbations, as in the case of NSP15, which causes the upregulation of over 2800 genes including networks associated with the activation the unfolded protein response (UPR) and the proinflammatory response associated with viral pathogenesis ( The above studies suggest a completely different role for viral proteins during the incubation period of the disease, when the immune response is inhibited, as opposed to the late phase of the disease, when there is hyperactivation of the immune system and a cytokine storm, as described in the earlier sections of this article