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Results Workflow of performed analyses In the present study we investigated two levels of interactions for agonists of the GLP1R, GIPR, and GCGR in following combinations: GLP1R (semaglutide), GLP1R/GIPR (tirzepatide), GLP1R/GIP and triple agonist GLP1R/GIPR/GCGR (retatrutide)

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An open-label trial by Mansur et al 23 reported that addition of liraglutide 1.8 mg daily to the existing medication regimen led to significant increases from baseline to week 4 in the Trail-Making Test-B standard score and in a composite Z-score comprising multiple cognitive tests