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Molecules used in chronic weight loss studies were generated by Amgen as previously described and dosing regimens for each molecule were established by previously published pharmacokinetic and pharmacodynamic studies: mGIPR-Ab (25 mg kg 1 every 6 days) 17 , dulaglutide (0.3 mg kg 1 every 3 days) 17 and mGIPR-Ab/P1 or mGIPR-Ab/P3 (1.5 mg kg 1 every 6 days) 16

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Vitamin E, 150IU: -Glutathione level is significantly related to Vitamin E level, and supplementation with Vitamin E (100 IU/day) significantly increases Glutathione and lowers lipid per-oxidation and HbA1c concentrations in the erythrocytes of type 1 diabetic patients