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This suggests the drug was engaging relevant pathways, just not sufficiently to translate to clinical benefit at this disease stage
(Science-Based Medicine) Cardiovascular effects rapid high-dose IV injections may cause vasodilation or sudden drop in blood pressure
Crucially, its enhanced metabolic stability and superior bioavailability enable it to readily traverse the blood-brain barrier, surpassing the therapeutic limitations of its parent molecule
Trials say no, but 5 indirect pathways explain lost sleep
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